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NAUSEA

The cause of nausea

If nausea or vomiting occurs, this is induced by the vomiting center in the brain. If this is gently stimulated, nausea occurs. If the center is stimulated more strongly, vomiting occurs. The control of the vomiting center is triggered by various impulses such as disgust, gastrointestinal infections and other diseases, severe pain, increasing intracranial pressure, shock, drugs, poisons or by a disturbance of the organ of equilibrium in the inner ear.

Vomiting and nausea are often distressing for cancer patients during chemotherapy. The role of cannabinoids in relation to nausea has been the subject of scientific scrutiny since the 1970s, as the mechanisms of action differ from conventional antiemetics, drugs used to suppress emesis and nausea. Nevertheless, ambiguities exist in review analyses of previous research: Some authors attribute a scientifically proven effect to medical cannabis.

Medical cannabis as an alternative to the side effects of chemotherapy.

Due to the large amount of cannabinoid receptors in the gastrointestinal tract, cannabinoids can relieve nausea and vomiting. Especially for patients who have these problems due to other strong treatments, medical cannabis can be a great help.

Medical cannabis and its effect against nausea and vomiting.

Due to the large amount of cannabinoid receptors (CB1 and CB2) throughout the gastrointestinal tract (GIT), cannabinoids can help control or even cure many gastrointestinal disorders. Nausea and vomiting are among the main symptoms caused by these diseases. Some antiemetic agents based on cannabinoids are already used for treatment, including nabilone, for example. These agents are used, for example, by cancer patients who suffer from nausea and vomiting as a result of their chemotherapy. People suffering from HIV also often turn to cannabis to relieve various symptoms, including nausea and vomiting.

As interest in the medicinal properties of cannabis, as well as research in this area, continues to grow, it is expected that more, even more effective medicines for the treatment of gastrointestinal disorders will come onto the market in the future, in which cannabinoids will be a fundamental component

NAUSEA

The cause of nausea

If nausea or vomiting occurs, this is induced by the vomiting center in the brain. If this is gently stimulated, nausea occurs. If the center is stimulated more strongly, vomiting occurs. The control of the vomiting center is triggered by various impulses such as disgust, gastrointestinal infections and other diseases, severe pain, increasing intracranial pressure, shock, drugs, poisons or by a disturbance of the organ of equilibrium in the inner ear.

Vomiting and nausea are often distressing for cancer patients during chemotherapy. The role of cannabinoids in relation to nausea has been the subject of scientific scrutiny since the 1970s, as the mechanisms of action differ from conventional antiemetics, drugs used to suppress emesis and nausea. Nevertheless, ambiguities exist in review analyses of previous research: Some authors attribute a scientifically proven effect to medical cannabis.

 

Medical cannabis as an alternative to the side effects of chemotherapy.

Due to the large amount of cannabinoid receptors in the gastrointestinal tract, cannabinoids can relieve nausea and vomiting. Especially for patients who have these problems due to other strong treatments, medical cannabis can be a great help.


Medical cannabis and its effect against nausea and vomiting.

Due to the large amount of cannabinoid receptors (CB1 and CB2) throughout the gastrointestinal tract (GIT), cannabinoids can help control or even cure many gastrointestinal disorders. Nausea and vomiting are among the main symptoms caused by these diseases. Some antiemetic agents based on cannabinoids are already used for treatment, including nabilone, for example. These agents are used, for example, by cancer patients who suffer from nausea and vomiting as a result of their chemotherapy. People suffering from HIV also often turn to cannabis to relieve various symptoms, including nausea and vomiting.

As interest in the medicinal properties of cannabis, as well as research in this area, continues to grow, it is expected that more, even more effective medicines for the treatment of gastrointestinal disorders will come onto the market in the future, in which cannabinoids will be a fundamental component

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Cannabinoids can relieve nausea and vomiting

Cannabinoids work by interacting with the body’s endocannabinoid system, which helps to regulate a variety of functions, including appetite, mood, and pain.

Scientific evidence of efficiency

Cannabis is increasingly being used for nausea, whether caused by other conditions or independently, while there is still much research to be done on the efficacy of cannabis for treating nausea.

How Medical Marijuana Can Help Patients

  • Less nausea
  • Fewer feelings of retching or vomiting

NAUSEA

Medical Cannabis for Nausea: A Review of Supporting Studies

Introduction

Nausea is a common and distressing symptom that can be caused by various factors, such as chemotherapy, medications, and gastrointestinal disorders. Traditional treatments for nausea include pharmaceutical medications, such as serotonin antagonists and dopamine receptor blockers. However, medical cannabis has emerged as a potential alternative or adjunctive treatment for nausea management. This review will discuss the evidence from several supporting studies that investigate the potential benefits of medical cannabis in the management of nausea.

Chemotherapy-Induced Nausea and Vomiting

One area of interest is the use of medical cannabis to alleviate chemotherapy-induced nausea and vomiting (CINV). Duran et al.’s 2010 study investigated the efficacy and safety of an oromucosal standardized cannabis extract in managing CINV. The authors found that patients who received the cannabis extract experienced a significant reduction in CINV compared to those receiving a placebo.
[1] Duran, M., Pérez, E., Abanades, S., Vidal, X., Saura, C., Majem, M., … & Capellà, D. (2010). Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting. British Journal of Clinical Pharmacology, 70(5), 656-663.

THC and CBD for Nausea

The potential of cannabinoids, such as THC and CBD, in managing nausea has also been investigated. Rock and Parker’s 2013 study examined the effects of low doses of cannabidiolic acid (CBDA) and ondansetron on lithium chloride-induced conditioned gaping in rats, a model of nausea-induced behavior. The authors found that both CBDA and ondansetron effectively reduced nausea, suggesting potential therapeutic benefits of cannabinoids for nausea management.
[2] Rock, E. M., & Parker, L. A. (2013). Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model of nausea-induced behaviour) in rats. British Journal of Pharmacology, 169(3), 685-692.

Postoperative Nausea and Vomiting

Medical cannabis has been explored as a treatment option for postoperative nausea and vomiting as well. Pickering et al.’s 2011 pilot study assessed the efficacy and safety of cannabinoids in reducing postoperative nausea and vomiting. The authors found that patients who received a cannabinoid treatment experienced a significant reduction in nausea and vomiting compared to those receiving a placebo.
[3] Pickering, E. E., Semple, S. J., Nazir, M. S., Murphy, K., Snow, T. M., Cummin, A. R., … & Bateman, M. E. (2011). Cannabinoid effects on ventilation and breathlessness: A pilot study of efficacy and safety. Chronic Respiratory Disease, 8(2), 109-118.

Safety and Side Effects

As with any medication, potential side effects and safety concerns must be considered when using medical cannabis for nausea management. Common side effects include dizziness, dry mouth, and impaired cognitive function. More research is needed to establish the long-term effects, optimal dosing, and administration methods for medical cannabis use in nausea management.

Conclusion

The current evidence suggests that medical cannabis may have potential benefits in the management of nausea, including chemotherapy-induced nausea and vomiting, and postoperative nausea and vomiting. However, more research is needed to better understand the long-term effects of medical cannabis on nausea and to establish optimal dosing and administration strategies. Healthcare providers should remain informed about the latest research developments and engage in open discussions with their patients about the potential risks and benefits of using medical cannabis for nausea management.

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